Wild-type dystrophin

Isoform full length sequences (cDNA and protein)

Exon sequences

1) Click on exon(s) in scheme to visualize sequence(s) in right box	2) Select sequence(s) in this area and copy it in a text file to retrieve it(them)

Or select all exons

Structural domain sequences

Click on structural domain(s) to see a table with all versions of the selected domain

Click here to see all short sequences between structural domains.

CH1

Source	Positions	Size
Norwood *	9 to 121	113
Banuelos	14 to 124	111
cd00014	16 to 119	104
smart00033	17 to 117	101
pfam00307	17 to 119	103

CH2

Source	Positions	Size
Norwood *	131 to 246	116
Banuelos	133 to 243	111
cd00014	135 to 240	106
smart00033	136 to 235	100
pfam00307	136 to 240	105

H1

Source	Positions	Size	Add Sequence below?
Koenig *	247 to 337	91

R1

Source	Positions	Size	Add Sequence below?
Winder *	338 to 446	109
Koenig	337 to 447	111

R2

Source	Positions	Size	Add Sequence below?
Winder *	447 to 557	111
Koenig	448 to 556	109

R3

Source	Positions	Size	Add Sequence below?
Winder *	558 to 668	111
Koenig	557 to 667	111

H2

Source	Positions	Size	Add Sequence below?
Koenig	668 to 717	50
Winder *	669 to 717	49

R4

Source	Positions	Size	Add Sequence below?
Winder *	718 to 828	111
Koenig	718 to 828	111

R5

Source	Positions	Size	Add Sequence below?
Winder *	829 to 937	109
Koenig	829 to 934	106

R6

Source	Positions	Size	Add Sequence below?
Winder *	938 to 1046	109
Koenig	935 to 1045	111

R7

Source	Positions	Size	Add Sequence below?
Winder *	1047 to 1155	109
Koenig	1046 to 1154	109

R8

Source	Positions	Size	Add Sequence below?
Winder *	1156 to 1264	109
Koenig	1155 to 1263	109

R9

Source	Positions	Size	Add Sequence below?
Winder *	1265 to 1368	104
Koenig	1264 to 1367	104

R10

Source	Positions	Size	Add Sequence below?
Winder *	1369 to 1460	92
Koenig	1368 to 1463	96

R11

Source	Positions	Size	Add Sequence below?
Winder *	1461 to 1569	109
Koenig	1464 to 1568	105

R12

Source	Positions	Size	Add Sequence below?
Winder *	1570 to 1677	108
Koenig	1569 to 1676	108

R13

Source	Positions	Size	Add Sequence below?
Winder *	1678 to 1781	104
Koenig	1677 to 1778	102

R14

Source	Positions	Size	Add Sequence below?
Winder *	1782 to 1875	94
Koenig	1779 to 1874	96

R15

Source	Positions	Size	Add Sequence below?
Winder *	1876 to 1973	98
Koenig	1875 to 1973	99

R16

Source	Positions	Size	Add Sequence below?
Winder *	1994 to 2102	109
Koenig	1992 to 2101	110

R17

Source	Positions	Size	Add Sequence below?
Winder *	2103 to 2209	107
Koenig	2102 to 2208	107

R18

Source	Positions	Size	Add Sequence below?
Winder *	2210 to 2319	110
Koenig	2209 to 2318	110

R19

Source	Positions	Size	Add Sequence below?
Winder *	2327 to 2427	101
Koenig	2319 to 2423	105

H3

Source	Positions	Size	Add Sequence below?
Winder *	2428 to 2468	41
Koenig	2424 to 2470	47

R20

Source	Positions	Size	Add Sequence below?
Winder *	2469 to 2578	110
Koenig	2471 to 2577	107

R21

Source	Positions	Size	Add Sequence below?
Winder *	2579 to 2687	109
Koenig	2578 to 2686	109

R22

Source	Positions	Size	Add Sequence below?
Winder *	2688 to 2803	116
Koenig	2687 to 2802	116

R23

Source	Positions	Size	Add Sequence below?
Winder *	2804 to 2932	129
Koenig	2803 to 2931	129

R24

Source	Positions	Size	Add Sequence below?
Winder *	2933 to 3040	108
Koenig	2932 to 3040	109

H4

Source	Positions	Size	Add Sequence below?
Koenig *	3041 to 3045	5

WW

Source	Positions	Size
Huang *	3046 to 3084	39
Ishikawa	3046 to 3084	39
Sudol	3055 to 3092	38
smart00456	3057 to 3088	32
cd00201	3059 to 3088	30
pfam00397	3060 to 3086	27

EFH1

Source	Positions	Size
pfam09068	3087 to 3207	121
Huang *	3125 to 3207	83
Ishikawa	3125 to 3207	83

EFH2

Source	Positions	Size
Huang *	3208 to 3290	83
Ishikawa	3208 to 3290	83
pfam09069	3211 to 3302	92

ZZ

Source	Positions	Size
Ishikawa	3307 to 3345	39
pfam00569	3307 to 3352	46
Hnia *	3307 to 3352	46
smart00291	3308 to 3351	44
cd02334	3311 to 3359	49
Hnia	3313 to 3340	28

C_term

Source	Positions	Size	Add Sequence below?
Koenig *	3353 to 3685	333

Linkers

Name	Source	Positions	Size
linker Met-CH1	Norwood *	1 to 8	8
linker CH1-CH2	Norwood *	122 to 130	9
linker R15-R16	Winder *	1974 to 1993	20
linker R18-R19	Winder *	2320 to 2326	7
linker WW-EFH1	Huang *	3085 to 3124	40
linker EFH2-ZZ	Huang *	3291 to 3306	16

Binding domain sequences

Click on arrows in scheme to see a table with all versions of the selected binding domain

K19

Source	Positions	Size	Add Sequence below?
Stone *	1 to 246	246

ABD1

Source	Positions	Size	Add Sequence below?
Norwood *	9 to 246	238
Banuelos	14 to 243	230

LBD1

Source	Positions	Size	Add Sequence below?
Legardinier *	338 to 668	331

LBD2

Source	Positions	Size	Add Sequence below?
Legardinier *	718 to 2423	1706

PAR-1b

Source	Positions	Size	Add Sequence below?
Yamashita *	1156 to 1368	213

ABD2

Source	Positions	Size	Add Sequence below?
Amann *	1461 to 2209	749

Synemin

Source	Positions	Size	Add Sequence below?
Bhosle *	1417 to 1915	499

nNOS

Source	Positions	Size	Add Sequence below?
Lai *	1994 to 2209	216

Plectin

Source	Positions	Size	Add Sequence below?
Rezniczek *	3046 to 3352	307

BDG

Source	Positions	Size	Add Sequence below?
Ishikawa	3046 to 3352	307
Huang *	3046 to 3290	245

Syntrophin

Source	Positions	Size	Add Sequence below?
Newey *	3501 to 3541	41

Dystrobrevin

Source	Positions	Size	Add Sequence below?
Sadoulet *	3501 to 3541	41

Synemin2

Source	Positions	Size	Add Sequence below?
Bhosle *	3051 to 3401	351

Myospryn

Source	Positions	Size	Add Sequence below?
Reynolds *	3069 to 3685	617

Ankyrin

Source	Positions	Size	Add Sequence below?
Ayalon *	3069 to 3427	359

3D-structure models

Crystallographic structures	Single repeat structure models	Tandem repeat structure models
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Chosen model:
	Exemple of 3D structure / model

	[Legrand et al., 2011]
Structure visualized with Jmol. Right Click to display menu. N-terminal is indicated by yellow ball.

Knowledge

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Mutated dystrophin

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